منابع مشابه
Synthesis of sulfazecin-type 2-azetidinones with a carbon substituent at the 4-position.
Sir: As reported in our previous paper,1) chemical modification of sulfazecin2) at the 3-position significantly enhanced its antibacterial activity; however, further improvement was desired especially in regard to the stability to some p-lactamases. We focused our attention on modifying the unexplored 4-position, and cis-1-(2,4dimethoxybenzyl)4methoxycarbonyl3 -phthalimido-2-azetidinone (1a) wa...
متن کاملLarge ring 1,3-bridged 2-azetidinones: experimental and theoretical studies.
The relationship between angular strain and (re)activity of bicyclic 2-azetidinones is still an open question of major concern in the field of penicillin antibiotics. Our study deals with original 13-membered-ring 1,3-bridged 2-azetidinones related to the carbapenem family, and featuring a "planar amide" instead of the "twisted amide" typical of penam derivatives. The bicycles 11 and 12 were ob...
متن کاملSynthesis and Antifungal Activity of Some Azetidinones
Ethyl-1H-benzotriazol-1-acetate 2 was prepared by reacting 1H-benzotriazole 1 in alcohol with ethyl bromoacetate in presence of anhydrous potassium carbonate, which was treated with hydrazine hydrate under reflux for 1824 hours to obtain the intermediate 1H-benzotriazole-1-acetic acid hydrazide 3. This compound on Schiff’s reaction with aromatic aldehydes in presence of solvent mixture yielded ...
متن کاملEstimation of Ozone Reactivities for Volatile Organic Compound Speciation Profiles in the Speciate 4 . 2 Database Prepared
Incremental reactivities for ground-level ozone formation were assigned for all volatile organic compound (VOC) emissions profiles in the Speciate 4.3 database. Best estimate and upper and lower limit reactivity values are given for the maximum incremental reactivity (MIR), maximum ozone incremental reactivity (MOIR) and equal benefit incremental reactivity (EBIR) calculated using the latest ve...
متن کاملSynthesis and biological evaluation of new 2-azetidinones with sulfonamide structures.
New series of N-(arylidene)hydrazinoacetyl sulfonamides 4a1-6, 4b1-6 and N-(4-aryl-3-chloro-2-oxoazetidin-1-yl)aminoacetyl sulfonamides 5a1-6, 5b1-6 were synthesized. The structures of the new derivatives was confirmed using spectral methods (FT-IR, 1H-NMR, 13C-NMR). The antibacterial activities of these compounds against Gram positive (Staphylococcus aureus ATCC 6583, Staphylococcus epidermidi...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1973
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.21.1305